The Molecular Vascular Bioengineering Laboratory at UCSD Bioengineering was established in 1988 when Dr. Shu Chien and several of his colleagues moved from Columbia University to San Diego. The Laboratory has grown from less than ten staff members to over twenty over the past decade. Our research goal is to elucidate the molecular mechanisms of the regulation of vascular functions, with a special emphasis on the transduction of mechanical stimuli, such as pressure and flow, into intracellular signaling and the ensuing gene expression and functional responses in health and disease.